Pioneer Transcription Factors Initiating Gene Network Changes
نویسندگان
چکیده
منابع مشابه
Cell fate control by pioneer transcription factors.
Distinct combinations of transcription factors are necessary to elicit cell fate changes in embryonic development. Yet within each group of fate-changing transcription factors, a subset called 'pioneer factors' are dominant in their ability to engage silent, unmarked chromatin and initiate the recruitment of other factors, thereby imparting new function to regulatory DNA sequences. Recent studi...
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A subset of eukaryotic transcription factors possesses the remarkable ability to reprogram one type of cell into another. The transcription factors that reprogram cell fate are invariably those that are crucial for the initial cell programming in embryonic development. To elicit cell programming or reprogramming, transcription factors must be able to engage genes that are developmentally silenc...
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The mammalian circadian clock relies on the master genes CLOCK and BMAL1 to drive rhythmic gene expression and regulate biological functions under circadian control. Here we show that rhythmic CLOCK:BMAL1 DNA binding promotes rhythmic chromatin opening. Mechanisms include CLOCK:BMAL1 binding to nucleosomes and rhythmic chromatin modification; e.g., incorporation of the histone variant H2A.Z. Th...
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This symposium on mechanisms in the development of early atheroma was held at the Ciba Foundation in London, July 5-6, 1972. For American students of atherosclerosis it differs both in the composition of the panel and in the selection of areas discussed. Only three of the 22 participants are from the United States. Eleven are from the United Kingdom, three from elsewhere in Europe, three from I...
متن کاملMitochondrial transcription factors TFAM and TFB2M regulate Serca2 gene transcription.
AIMS Sarco(endo)plasmic reticulum Ca²(+)-ATPase 2a (SERCA2a) transports Ca²(+) by consuming ATP produced by mitochondrial respiratory chain enzymes. Messenger RNA (mRNA) for these enzymes is transcribed by mitochondrial transcription factors A (TFAM) and B2 (TFB2M). This study examined whether TFAM and TFB2M coordinately regulate the transcription of the Serca2 gene and mitochondrial genes. M...
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ژورنال
عنوان ژورنال: Annual Review of Genetics
سال: 2020
ISSN: 0066-4197,1545-2948
DOI: 10.1146/annurev-genet-030220-015007